Northwestern MSTP Students' Awards, Fellowships, and Publications in 2007-2008 Congratulations to the 3 who received Malkin Scholarships, to the 8 who received prestigious external awards, to the 24 students awarded pre-doctoral fellowships in 2007, and to the 30 students who collectively published 52 papers in 2006! Malkin Scholarships Were Awarded to 3 MSTP Students for Cancer Research in 2007 David Salvay (Grad 3), Department of Chemical and Biological Engineering Cory Simpson (Grad 2), Department of Pathology Mandy Redig (Grad 2), Department of Medicine and Lurie Cancer Center Prestigious External Awards to 7 MSTP Students Hans Arora (Grad1) received an AMA Leadership Award given annually to 56 medical students, residents, and ealry career physicians who display strong non-clinical leadership skills in advocacy, community service, public health or education. Prajwal Ciryam (Med 1) and two fellow Northwestern students received a Mabie Global Health Fellowship to support his summer 2007 health services research project on cataract surgery in Ghana and India. Alison Christy (Grad2) received the Alpha Omega Alpha (AOA) 2005 Helen Glaser National Writing Award. Tracy Gertler (Grad1) and Blayne Sayed (Grad3) received Schweitzer Fellowships from the Albert Schweitzer Foundation. Sara Kleinschmidt (Med2) received the American Neurology Association's 2007 Student Essay Award. Amanda Redig (Grad2) received the American Medical Association's 2006 Conley Ethics Essay Award. David Salvay (Grad 3), Department of Chemical and Biological Engineering received the Endocrine Society's 2007 Anthony R. Means Basic Science Student Award Individual Predoctoral Fellowships Awarded to 26 MSTP Students in 2007 MSTP Student Pre-doctoral Fellowship Thesis Adviser Ramona Bhattacharya American Heart Association Predoctoral Fellowship, 2005-2007 Dr. Jonathan Jones Brian Emmer American Heart Association Predoctoral Fellowship, 2005-2007 Dr. David Engman Amanda Zubek American Heart Association Predoctoral Fellowship, 2006-2008 Dr. Kathy Green Aaron Miller American Heart Association Predoctoral Fellowship, 2006-2008 Dr. David Dean Sebastian Fernandez-Pol American Heart Association Predoctoral Fellowship , 2007-2009 Dr. Kasturi Haldar Robbie Cantrell National Defense Science and Engineering Graduate Fellowship, US Department of Defense, 2005-2008 Dr. John Troy Richard Ahn Predoctoral Traineeship, Breast Cancer Program, US Department of Defense, 2007-2010 Dr. Thomas O'Halloran Siri Sonty Chicago Department of Public Health, Alzheimer's Disease Research Fellowship, 2006-2007 Drs. Marsel Mesulam & Darren Gitelman Tracy Gertler NIMH-NIH, National Service Research Award, 2007-2009 Dr. D. James Surmeier Vanderlene Kung NIEHS-NIH, National Service Research Award, 2007-2011 Dr. Alan Hauser Sarah Umetsu NIEHS-NIH, National Service Research Award, 2007-2011 Dr. Susan Winandy Matthew Reynolds NINDS, National Service Research Award, 2004-2008 Dr. Lester Binder Peleg Horowitz NINDS-NIH, National Service Research Award, 2004-2007 Dr. Lester Binder Ali Jalalali NINDS-NIH, National Service Research Award, 2005-2009 Dr. Jack Kessler Erick Lin NINDS-NIH, National Service Research Award, 2004-2008 Dr. Pat Spear Gregory Woodhead NINDS-NIH, National Service Research Award, 2005-2009 Dr. Anjen Chenn Laurie Eldredge NINDS-NIH, National Service Research Award, 2005-2007 Dr. Warren Tourtellotte John Cieslak NIH-NINDS, National Service Research Award, 2006-2008 Dr. Adrian Gross Blayne Amir Sayed NINDS-NIH, National Service Research Award, 2005-2008 Dr. Melissa Brown Cory Simpson NIEHS-NIH, National Service Research Award, 2006-2010, the Malkin Scholarship, 2007, and the Northwestern University Presidential Fellowship, 2007-2008 Dr. Kathy Green Chris Mutch NINDS-NIH, National Service Research Award, 2006-2010 Dr. Anjen Chenn Tina Pejchal NINDS-NIH, National Service Research Award, 2006-2011 Dr. Joe Takahashi David Salvay NIBIB-NIH, National Service Research Award, 2006-2008 and the Malkin Scholarship, 2007 Dr. Lonnie Shea Michael Lenaeus NINDS-NIH, National Service Research Award, 2007-2011 Dr. Adrian Gross Amanda Redig NIEHS-NIH, National Service Research Award, 2007- 2011 Dr. Leonidas Platanias Benjamin Chen Northwestern University Presidential Fellowship, 2006-2007 Dr. Robert Lamb

30 MSTP Students Published 54 Articles during 2006

Hans Arora, second year medical student, Laboratory of Dr. Tom Meade, Department of Chemistry

• Chong HS, Milenic DE, Garmestani K, Brady ED, Arora HC, Pfiester C, Brechbiel MW. 2006. In vitro and in vivo evaluation of novel ligands for radioimmunotherapy. Nucl Med Biol 33, 459-467.

Oneil Bhalala, first year medical student, Laboratory Undetermined

• Smukste I, Bhalala O, et al. 2006. Using small molecules to overcome drug resistance induced by a viral oncogene.  Cancer Cell. Feb, Vol 9.

Ramona Bhattacharya, third year graduate student, Laboratory of Dr. Jonathan Jones, Department of Cell and Molecular Biology

• Diehn M, Bhattacharya R, Botstein D, Brown PO. 2006. Genome-scale identification of membrane-associated human mRNAs. PLoS Genet. 13;2(1):e11.   

Mei Lin Bissonnette, fourth year graduate student, Laboratory of Dr. Robert Lamb, Department of Biochemistry, Molecular Biology, and Cell Biology

• Bissonnette MZ, Connolly SA, Young DF, Randall RE, Paterson RG, and Lamb RA. 2006. Analysis of the pH requirement for membrane fusion of different isolates of the paramyxovirus parainfluenza virus 5. J. Virol. 80:3071-3077.

Robbie Cantrell, third year graduate student, Laboratory of Drs. John Troy and Rod Ruoff, Departments of Biomedical Engineering and Mechanical Engineering

• Chen X, Cantrell, DR, Kohlhaas K, Stankovich S, Ibers JA, Jaroniec M, Gao H, Li X, Ruoff R. 2006. Carbide-Derived Nanoporous Carbon and Novel Core-Shell Nanowires. Chemistry of Materials 18, 753-758.

Ty Cashen, second year medical student, completed PhD in Laboratory of Dr. Timothy Carroll, Department of Biomedical Engineering

• Cashen TA, Jeong H, Shin W, Carr JC, Walker MT, Carroll TJ. 2006. 4D radial contrast-enhanced MR angiography with sliding subtraction.  Magn Reson Med. (in press).
• Park JK, Cashen TA, Shin W, Rhee TK, Carroll TJ, Omary RA. 2006. 3.0T MRI assessment of renal function during angioplasty of renal artery stenosis in swine.  Radiology (in press).
• Rhee TK, Park JK, Cashen TA, Shin W, Schirf BE, Gehl JA, Larson AC, Carr JC, Li D, Carroll TJ, Omary RA. 2006. Comparison of intraarterial MR angiography at 3.0 T with X-ray digital subtraction angiography for detection of renal artery stenosis in swine. J Vasc Interv Radiol 17(7):1131-1137.
• Shin W, Cashen TA, Horowitz S, Sawlani R, Carroll TJ. 2006. Quantitative CBV measurement from static T1 changes in tissue and correction for intravascular water exchange.  Magn Reson Med 56(1):138-145.
• Shaibani A, Khawar S, Shin W, Cashen TA, Schirf B, Rohany M, Kakodkar S, Carroll TJ. 2006. First results in an MRI compatible canine model of acute stroke.  AJNR Am J Neuroradiol 27(8):1788-1793.
• Cashen TA, Carr JC, Shin W, Walker MT, Futterer SF, Shaibani A, McCarthy RM, Carroll TJ. 2006. Intracranial time-resolved contrast-enhanced MR angiography at 3 T.  AJNR Am J Neuroradiol 27(4):822-829.

Benjamin Chen, fourth year graduate student, Laboratory of Dr. Robert Lamb, Department of Biochemistry, Molecular Biology, and Cell Biology

• Vega RA, Maspoch D, Shen CK-F, Kakkassary J, Chen BJ, Lamb RA, and CA Mirkin. 2006. Functional antibody arrays through metal ion-affinity templates.  ChemBioChem.  7:1653-1657.

John Cieslak, third year graduate student, Laboratory of Dr. Adrian Gross, Department of Molecular Pharmacology and Biological Chemistry

• Vamvouka M, Cieslak JA, and Gross A.  2006.  The native structure of the KvAP voltage sensor paddle in lipid bilayers determined by double electron-electron resonance spectroscopy.

Jeffrey Craft, fourth year medical student, PhD in the Laboratory of Dr. Linda Van Eldik, Department of Cell and Molecular Biology

• Craft JM, Watterson DM, Van Eldik LJ. 2006.Human amyloid beta-induced neuroinflammation is an early event in neurodegernation. Glia 53(5):484-90.
• Ralay Ranaivo H, Craft JM, Hu W, Guo L, Wing LK, Van Eldik LF, Watterson DM. 2006.Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration. J Neurosci 26(2):662-670.

Joseph Evans, fourth year graduate student, Laboratory of Dr. Vincent Cryns, Department of Cell and Molecular Biology

• Moyano JV, Evans JR, et al. 2006. AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer. J Clin Invest 116 (1): 261-70.
• Yehiely F, Moyano JV, Evans JR, Nielsen TO, Cryns VL.  Deconstructing the molecular portrait of basal-like breast cancer.  Trends Mol Med. 2006 Nov;12(11):537-44. Epub 2006 Sep 29.

Maxfield Flynn, fourth year graduate student, Laboratory of Dr. Mary Hunzicker-Dunn, Department of Cell and Molecular Biology

• Flynn MP and Hurley DL. 2006. Growth hormone transcription factor ZN-16 genomic coding regions are composed of a single exon and are evolutionarily conserved in mammals. Gene 368, 78-83.

John Graham, first year medical student, Laboratory Undetermined

• Nishiguchi GA, Graham J, Bouraoui A, Jacobs RS, Little RD. 2006. 7,11-Epi-Thyrsiferol: Completion of its Synthesis, Evaluation of its Antimitotic Properties, and the Further Development of an SAR Model, J. Org. Chem. 71(16), 5936-5941.

Sharron Hart, third year medical student, Laboratory of Dr. Catherin Woolley, Department of Neurobiology and Physiology

• Hart SA, Snyder MA and CS Woolley. 2006. Estrogen mobilizes a subset of estrogen receptor-a-containing vesicles in inhibitory presynaptic boutons in hippocampal CA1. J. Neurosci., In Press.

Peleg Horowitz, third year medical student, Laboratory of Dr. Lester Binder, Department of Cell and Molecular Biology

• Sengupta S*, Horowitz PM*, Karsten SL, Jackson GR, Geschwind DH, Fu Y, Berry RW, and Binder LI. 2006. Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro.  Biochemistry 45: 15111-9. * co-first authors


• Horowitz PM*, LaPointe N*, Guillozet-Bongaarts AL, Berry RW, and Binder LI. 2006. N-terminal fragments of tau inhibit full-length tau polymerization in vitro.  Biochemistry 45:12859-66. * co-first authors

Ali Jalali, fourth year gradaute student, Laboratory of Dr. John Kessler, Department of Neurology Department

• Jalali A, Bassuk AG, Israsena N, Hu M, Kessler JA. HeyL Promotes Neuronal Lineage Commitment by Neural Progenitor Cells. Development, In Press.
• Kan L, Jalali A, Zhao L, Zhou X, McGuire T, Kazanis I, Episkopou V, Bassuk AG, Kessler JA. Dual Function of Sox1 in Telencephalic Progenitor Cells. Developmental Biology. In Press.

Jacob Keller, third year graduate student, Laboratory of Dr. Ted Jardetzky, Department of Biochemistry, Molecular Biology, and Cell Biology

• Zheng J, Du G, Anderson CT, Keller JP, Orem A, Dallos P, Cheatham MA. 2006. Analysis of the oligomeric structure of the motor protein prestin. J Biol Chem. Jul 21;281(29):19916-24. Epub 2006 May 8.

Austin Kirschner, third year graduate student, Laboratory of Dr. Ted Jardetzky, Department of Biochemistry, Molecular Biology, and Cell Biology

• Kirschner AN, Omerović J, Popov B, Longnecker R, Jardetzky TS. 2006. Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion, J. Virol. 80(19), 9444-9454.

Alan Lewis, first year medical student, Laboratory Undetermined

• Hansen DB, Lewis AS, Gavalas SJ and Joullié MM. 2006. A stereoselective synthetic approach to (2S, 3R)-N-(1',1'-dimethyl-2',3'-epoxypropyl)-3-hydroxytryptophan, a component of cyclomarin A. Tetrahedron Asymmetry. 17, 15-21.

Jeffrey Mercer, third year medical student, Laboratory of Dr. Jim Surmeier, Department of Physiology Department

• Chan CS, Guzman-Lucero JN, Ilijic E, Mercer JN, Rick C, Tkatch T, Surmeier DJ. 2006. Rejuvenation of substantia nigra dopaminergic neurons confers protection from the mitochondrial toxin rotenone,

Sean Murphy, third year medical student, PhD in the Laboratory of Dr. Kastuir Haldar, Department of Pathology

• Murphy SC, Harrison T, Lomasney J, Hamm H, Mohandas N, Haldar K. 2006. Erythrocyte G Protein as a Novel Target for Malarial Chemotherapy. PLoS Med, .
• Chaudhari A, Fialho AM, Ratner D, Gupta P, Hong CS, Kahali S, Yamada T, Haldar K, Murphy S, Cho W, Chauhan VS, Das Gupta TK, Chakrabarty AM. 2006. Azurin, Plasmodium falciparum malaria and HIV/AIDS. Cell Cycle. 5(15):e1-e7.
  
• Murphy S. Malaria and global infectious diseases: why should we care? Virtual Mentor (AMA) April 2006. 8:245-250.
  
• Murphy SC, Hiller NL, Harrison T, Lomasney JW, Mohandas N, Haldar K. 2006. Lipid rafts and malaria parasite infection of erythrocytes (review). Molecular Membrane Biology, 23(1):81-88.
  
• Haldar K, Murphy SC, Milner DA, Taylor TE. Malaria: mechanisms of erythrocytic infection and pathological correlates of severe disease (review). Annual Review of Pathology: Mechanisms of Disease, February 2007 vol. 2.

Chris Mutch, third year graduate student, Laboratory of Dr. Anjen Chenn, Department of Pathology

• Woodhead, G., Mutch, C., Olsen, G. and Chenn, A. 2006. Cell-Autonomous Beta-catenin Signaling Regulates Cortical Progenitor Proliferation.  The Journal of Neuroscience,

Amanda Redig, second year graduate student, Laboratory of Dr. Leon Platanias, Cancer Center

• Redig AJ. 2006. A Piece of My Mind. Jigsaw. Journal of the American Medical Association 295(4): 363-364.
• Yoon P, Giafis N, Smith J, Mears H, Katsoulidis E, Sassano A, Altman J, Redig AJ, Tallman M, Platanias LC. 2006. Activation of mTOR and the p70 S6 kinase by arsenic trioxide in BCR-ABL expressing cells. Molecular Cancer Therapeutics, 5(11), 2006.

Matthew Reynolds, third year medical student, PhD in the Laboratory of Dr. Lester Binder, Department of Cell and Molecular Biology

• Guillozet-Bongaarts AL , Cahill ME, Cryns VL, Reynolds MR, Berry RW, and Binder LI. 2006. Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo, J. Neurochem, In Press.
• Reynolds MR, Lukas TJ, Berry RW, and Binder LI. 2006. Peroxynitrite-mediated tau modifications stabilize preformed filaments and destabilize microtubules through distinct mechanisms, Biochemistry 45(13):4314-26.

David Salvay, third year graduate student, Laboratory of Dr. Lonnie Shea, Department of Chemical and Biological Engineering

• Salvay DM and Shea LD. 2006. Inductive tissue engineering with protein and DNA-releasing scaffolds. Molecular BioSystems 2(1): 36-48.

Jessica Schulte, first year medical student, Laboratory Undetermined

• Schulte, J. The role of mDPY-19-1 in neuronal migration. 2006. Chicago Biological Investigator, 3(2): 25.

Luke Sebel, first year medical student, Laboratory Undetermined

• Sebel LE, Richardson JE., Singh SP., Bell S, Jenkins, A. 2006. Additive Effects of Sevoflurane and Propofol on [gamma]-Aminobutyric Acid Receptor Function.  Anesthesiology. 104(6):1176-1183.

Ciara Shaver, third year medical student, Ph.D. in the Laboratory of Dr. Alan Hauser, Department of Microbiology-Immunology

• Shaver CM and Hauser AR. 2006. Interactions between effector proteins of the Pseudomonas aeruginosa type III secretion system do not significantly affect several measures of disease severity in mammals. Microbiology 152:143-152.

Siri Sonty, fourth year graduate student, Laboratory of Drs. Darren Gitelman and Marcel Mesulam, Department of Neurology

• Sonty SP, Mesulam MM, Weintraub S, Johnson NA, Parrish TB, Gitelman DR. Altered effective connectivity within the language network in Primary Progressive Aphasia. 2006. Journal of Neuroscience (In Press).

Cory Simpson, second year graduate student, Laboratory of Dr.Kathy Green, Department of Pathology

• Getsios S, Sheu LJ, Dusek RL, Simpson CL, Cornwell ML, Gocken T, Crawford SE, Green KJ (2006):  Transcending adhesive functions of desmosomal cadherins:  dual roles for desmoglein 1 in human epidermal integrity and morphogenesis.  In revision.
• Simpson CL, Green KJ (2006):  Identification of desmogleins as disease targets.  In Milestones in Investigative Dermatology: The Desmosome.  Journal of Investigative Dermatology.  In Press.

• Simpson CL (2006):  The ABCs of melanoma: expanding basic screening and education.  Virtual Mentor (American Medical Association Journal of Ethics), 8:517-19. Available at: http://www.ama-assn.org/ama/pub/category/16565.html.
• Getsios S, Sheu LJY, Dusek RL, Simpson C, Gocken T, Cornwell ML, Crawford S, Green KJ (2006):  Desmoglein 1 coordinates early morphogenetic events during human epidermal development in vitro.  Annual Meeting, Society for Investigative Dermatology, Philadelphia, PA.  Journal of Investigative Dermatology, 126:70.

Craig Smuda, first year medical student, Laboratory Undetermined

• Bailey SL, Schriener BS, McMahon EJ, Smuda CA, Miller SD. 2006. “CNS Myeloid Dendritic Cells Presenting Endogenous Myelin Peptides Preferentially Polarize CD4+ Th17 Cells in Relapsing EAE.”  In Press.

Tarita Thomas, fourth year medical student, PhD in the Laboratory of Dr. Heidi Hamm, now at Vanderbilt University

• Lorch JH, Thomas TO, Schmoll H. 2006. Bortezomib inhibits cell-cell adhesion and cell migration, induces recruitment of activated FAK to the membrane and enhances EGF-R inhibitor induced cell death in squamous cell cancer. Cancer Research,
• Gheorghiade M, Shinn DD, Thomas TO, Brandimarte F, Fonarow GC, Abraham WT. 2006. Congestion is an important diagnostic and therapeutic target in heart failure.  Rev Cardiovasc Medicine 7 Suppl 1: S12-24.

Gregory Woodhead, fourth year graduate student, Laboratory of Dr. Anjen Chenn, Department of Pathology

• Woodhead, G., Mutch, C., Olsen, G. and Chenn, A. 2006. Cell-Autonomous Beta-catenin Signaling Regulates Cortical Progenitor Proliferation.  The Journal of Neuroscience,

Amanda Bass-Zubek, fourth year graduate student, Laboratory of Dr. Kathleen Green, Department of Pathology

• Chen XC*, Bass-Zubek AE*, Hatzfeld M, Green KJ. 2006. Novel functions of plakophilin 2 in modulating cell morphology and adherens junctions. In Revision.
  
• Bass-Zubek AE, Green KJ. 2006. Milestones in Investigative Dermatology: The desmosome.  Biochemical characterization of the desmosome. Journal of Investigative Dermatology. 01/31/2008 E.
• Bass AE, Green KJ. 2006.  Desmosomes.  Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer International. Ganten, D., Ruckpaul, K., eds. Part 4: 387-391.